Figure 2. FOXA1/ER signalling in breast cancer.
(A) Lineage-specific FOXA1-binding sites are marked by histone H3, lysine 4 dimethylation (H3K4me2). FOXA1 mediates both oestrogen-induced gene transactivation and repression. (B) FOXA1 is necessary for ER expression, and expression of ER has been proposed to modulate FOXA1 expression in an oestrogen-dependent manner.