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. 2015 Jun 18;2015(6):CD010856. doi: 10.1002/14651858.CD010856.pub2

Wang 1993.

Methods FLUOROSIS STUDY
Country of study: China
Geographic location: Hotan, Kaxgar and Aksu, in south Xinjiang
Year of study: 1991
Year of change in fluoridation status: NA
Study design: cross‐sectional
Participants Inclusion criteria: children aged from 8‐15 years living around the water source
Exclusion criteria: not stated
Other sources of fluoride: not stated
Social class: farmers and herdsmen in south Xinjiang
Ethnicity: Minority, mainly Uygur ethnic group
Residential history: living in study area for a long time ("since many years ago")
Other confounding factors: the combined effects of iodine deficiency and high fluorine; the habit of tea drinking
Interventions All natural fluoridation
Group 1: 1.58 ppm
Group 2: 1.85‐2.00 ppm
Group 3: 0.48 ppm
Group 4: 2.55 ppm
Group 5: 0.43 ppm
Group 6: 0.46 ppm
Group 7: 0.43 ppm
Outcomes Dental fluorosis (index not stated)
Age at assessment: 15 years
Funding Not stated in translation
Notes Paper translated from Chinese
Risk of bias
Bias Authors' judgement Support for judgement
Sampling Unclear risk Children aged 8‐15 living in the vicinity of the water sources were included. Insufficient sampling information
Confounding High risk Did not account for the use of fluoride from other sources, residential history not clearly stated
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Not reported
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Data for all participants reported
Selective reporting (reporting bias) Low risk Outcome of interest presented
Other bias Unclear risk Unable to identify information pertaining to the training/reliability of outcome assessors