Fig. 1.
An overview of the study design. The study cohort comprised children who progressed to type 1 diabetes, children who seroconverted to one islet autoantibody but did not progress to type 1 diabetes during the follow-up, and a group who remained islet-autoantibody-negative during the follow-up until the age of 15 years. For each child, longitudinal plasma samples were drawn, corresponding to the ages of 3, 6, 12, 18, 24 and 36 months. In each age cohort and study group, the number of autoantibody-positive children is marked and represented with a Y (antibody) shape. TOF, time of flight