Table 1.
Demographics of Participants in Clinical Antidepressant Trials
| No active SI during research participation (n = 206) | Active SI during research participation (n = 63) | |||
|---|---|---|---|---|
|
| ||||
| Mean(SD) | Mean(SD) | t | p | |
| Age | 43.54(11.69) | 45.54(12.98) | 1.16 | .25 |
| Age of Onset | 21.65(10.95) | 18.56(11.07) | 1.94 | .054 |
| MADRS Score at Baseline (suicide item removed) | 28.74(6.37) | 32.02(6.32) | 3.16 | .002 |
| MADRS Suicide Item at Baseline | 1.25(0.89) | 2.95(1.09) | 11.92 | <.001 |
| N(%) | N(%) | X2 | p | |
| Gender | 2.56 | .11 | ||
| Male | 94(46) | 36(57) | ||
| Female | 112(54) | 27(43) | ||
| Diagnoses | 8.13 | .02 | ||
| Bipolar I | 19(9) | 12(19) | ||
| Bipolar II | 13(6) | 8(13) | ||
| MDD | 174(84) | 43(68) | ||
| History of Suicide Attempt | 32(16) | 26(41) | 15.54 | <001 |
| Comorbid Diagnosis | 122(59) | 32(51) | 1.40 | .24 |
| History of Abuse | 85(41) | 23(37) | 0.53 | .47 |
| Substance Abuse History | 77(37) | 29(46) | 1.95 | .16 |
| TRD Protocol | 154(75) | 56(89) | 5.63 | .02 |
| Completed Study | 159(77) | 42(67) | 2.82 | .09 |
SI: suicidal ideation; MADRS: Montgomery-Asberg Depression Rating Scale; MDD: major depressive disorder; TRD: treatment-resistant depression