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. 2016 Sep 21;104(5):1441–1449. doi: 10.3945/ajcn.116.130518

TABLE 3.

PLS-based feature selection of cytokines that differentiate groups of children with severe acute malnutrition who had diarrhea or died1

Diarrhea
 Death
Cytokine Component 1 (Cor: 0.49; R2: 0.24; Q2: 0.08)2 Feature stability,3 % Component 1 (Cor: 0.60; R2: 0.36; Q2: 0.18)2 Feature stability,3 %
1 EGF 0.314 — 0.15 —
2 Eotaxin 0.14 — −0.03 —
3 GCSF 0.644 100 0.684 90
4 GMCSF 0.534 — 0.414 —
5 IFNα2 0.594 100 0.484 70
6 IFNγ 0.394 — 0.17 —
7 IL10 0.26 — 0.29 —
8 IL12p40 0.26 — 0.11 —
9 IL12p70 0.644 100 0.554 80
10 IL13 0.354 — 0.54 100
11 IL15 0.594 — 0.584 70
12 IL17A 0.08 — 0.19 —
13 IL1RA 0.654 50 0.754 100
14 IL1α 0.16 — 0.12 —
15 IL2 0.744 100 0.744 100
16 IL5 0.24 — 0.17 —
17 IL6 0.564 100 0.614 100
18 IL7 0.26 — 0.364 —
19 IL8 0.34 — 0.44 —
20 IP10 0.28 — 0.14 —
21 MCP1 0.344 — 0.334 —
22 MIP1α 0.21 — 0.02 —
23 MIP1β 0.07 — 0.03 —
24 TNF-α 0.374 100 0.334 100
25 TNF-β 0.564 100 0.554 100
26 VEGF 0.24 — 0.23 —
1

IL3, IL4, and IL1β were not analyzed because they were undetected in most samples. EGF, epidermal growth factor; GCSF, granulocyte-colony stimulating factor; GMCSF, granulocyte-macrophage colony stimulating factor; IFN, interferon; IP, induced protein; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; PLS, partial least square; VEGF, vascular endothelial growth factor.

2

Cor indicates the correlation strength between the PLS-component 1 and either diarrhea or death. R2 indicates the variance explained by component 1. Q2 indicates the predictive quality of component 1; Q2 is equal to 1 minus the prediction error sum of squares divided by the total sum of squares of the response variable; negative Q2 values indicate that the component is not predictive.

3

Feature stability indicates the percentage of times that a cytokine was selected as a top-10 feature by using sparse PLS with 10-fold cross-validation.

4

Correlation >0.3 with component 1.

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