Skip to main content
. 2016 Sep 21;104(5):1441–1449. doi: 10.3945/ajcn.116.130518

TABLE 3.

PLS-based feature selection of cytokines that differentiate groups of children with severe acute malnutrition who had diarrhea or died1

Diarrhea
Death
Cytokine Component 1 (Cor: 0.49; R2: 0.24; Q2: 0.08)2 Feature stability,3 % Component 1 (Cor: 0.60; R2: 0.36; Q2: 0.18)2 Feature stability,3 %
1 EGF 0.314 0.15
2 Eotaxin 0.14 −0.03
3 GCSF 0.644 100 0.684 90
4 GMCSF 0.534 0.414
5 IFNα2 0.594 100 0.484 70
6 IFNγ 0.394 0.17
7 IL10 0.26 0.29
8 IL12p40 0.26 0.11
9 IL12p70 0.644 100 0.554 80
10 IL13 0.354 0.54 100
11 IL15 0.594 0.584 70
12 IL17A 0.08 0.19
13 IL1RA 0.654 50 0.754 100
14 IL1α 0.16 0.12
15 IL2 0.744 100 0.744 100
16 IL5 0.24 0.17
17 IL6 0.564 100 0.614 100
18 IL7 0.26 0.364
19 IL8 0.34 0.44
20 IP10 0.28 0.14
21 MCP1 0.344 0.334
22 MIP1α 0.21 0.02
23 MIP1β 0.07 0.03
24 TNF-α 0.374 100 0.334 100
25 TNF-β 0.564 100 0.554 100
26 VEGF 0.24 0.23
1

IL3, IL4, and IL1β were not analyzed because they were undetected in most samples. EGF, epidermal growth factor; GCSF, granulocyte-colony stimulating factor; GMCSF, granulocyte-macrophage colony stimulating factor; IFN, interferon; IP, induced protein; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; PLS, partial least square; VEGF, vascular endothelial growth factor.

2

Cor indicates the correlation strength between the PLS-component 1 and either diarrhea or death. R2 indicates the variance explained by component 1. Q2 indicates the predictive quality of component 1; Q2 is equal to 1 minus the prediction error sum of squares divided by the total sum of squares of the response variable; negative Q2 values indicate that the component is not predictive.

3

Feature stability indicates the percentage of times that a cytokine was selected as a top-10 feature by using sparse PLS with 10-fold cross-validation.

4

Correlation >0.3 with component 1.