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. Author manuscript; available in PMC: 2017 Jan 13.
Published in final edited form as: Cell Host Microbe. 2016 Jan 13;19(1):44–54. doi: 10.1016/j.chom.2015.12.003

Figure 5. Blockade of antigen export from infected DC enhances overall antigen-specific CD4 T cell activation in vivo.

Figure 5

Comparison of Ag85B-specific CD4 T cell proliferation in MHC II+/+ recipients following transfer of infected kinesin-2 depleted or control MHC II+/+ DC. (A) Frequency of Ag85B-specific P25TCR-Tg CD4+ T cells in lymph nodes. (B) Quantitation of total P25TCR-Tg CD4+ T cells in lymph nodes of groups of mice shown in A. (C) Proportion of P25TCR-Tg cells that underwent ≥1 cycle of proliferation (CFSEdim) in lymph nodes of groups of mice shown in A. (D) Quantitation of P25TCR-Tg cells that underwent ≥1 cycle of proliferation (CFSEdim) in lymph nodes of groups of mice in C. Data are mean ± SEM of four pools of mice (n=8) per experimental group and represent 2 independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001 (Student's t-test).