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Inhibition of the D1-R reduces dopamine (Dopa) inotropy in PAH-RVH. A–D and I, Representative traces and mean data from the RV Langendorff model show that the selective antagonist of D1-R, SCH23390, does not change the RV response to dobutamine (Dobu) in control or MCT rats. E–H and J, SCH23390 decreases the RV response to dopamine in MCT but not CTR. RV indicates right ventricular; RVSP, right ventricular systolic pressure; MCT, monocrotaline; and CTR, control.
