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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Mol Med (Berl). 2013 Jun 21;91(10):1185–1197. doi: 10.1007/s00109-013-1064-7

Fig 7. Chronic DON treatment decreases glutaminolysis.

Fig 7

A-B. DON reduces cMyc, SLC1A5, SLC7A5 mRNA expression in RV myocyte cytosol in Monocrotaline-RVH.

C. Decreased cytosol Me1 expression in Monocrotaline-RV, which is slightly increased by DON. Mitochondrial Me2 mRNA expression is increased in Monocrotaline-RV and reduced by chronic DON.

D. Representative image and mean data showing that RV PDH activity is reduced in Monocrotaline-RVH and normalized by chronic DON.