Table 3.
A summary of small molecule inhibitors targeting 19S regulatory particle of the proteasome and the DUBs.
| Targets | Biological effects | Inhibitors | Refs. |
|---|---|---|---|
| Ub–Ub interface | Substrate recognition by the 19S regulatory particle | Ubistatins | [87] |
| USP14 and UCH-L5/UCH37 | Proteasome-associated DUB, antagonize substrate degradation | b-AP15 | [88] |
| USP7/HAUSP | Deubiquitinates p53 and Hdm2, redistributes | P5091 | [89] |
| PTEN subcellular localization | P22077 | [90] | |
| HBX19818 | [91] | ||
| Multiple DUBs including USP9x, USP5, USP14, and UCH-L5/UCH37 | Regulate survival protein stability and 26S proteasome function | WP-1130 | [92] |