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. Author manuscript; available in PMC: 2013 Oct 25.
Published in final edited form as: N Engl J Med. 2013 Apr 25;368(17):1575–1584. doi: 10.1056/NEJMoa1109400

Table 1.

Baseline Characteristics of the Participants in the Clinical-Outcomes Study, According to Status with Respect to Major Adverse Cardiovascular Events at 3 Years.*

Characteristic All Participants
(N = 4007)
Participants
without Events
(N = 3494)
Participants
with Events
(N = 513)
P Value
Age — yr 63±11 62±11 68±10 <0.001
Male sex — % 64 65 62 0.16
Median body-mass index (interquartile range) 28.7 (25.6–32.5) 28.7 (25.7–32.5) 28.1 (24.8–32.4) 0.03
Diabetes mellitus — % 32 30 43 <0.001
Hypertension — % 72 71 79 <0.001
History of myocardial infarction — % 42 40 53 <0.001
No. of coronary vessels with ≥50% stenosis — %
  0 26 28 15 <0.001
  1 20 21 15 0.004
  2 20 20 21 0.51
  3 34 32 48 <0.001
Current or former smoker — % 65 65 69 0.05
Median cholesterol (interquartile range) — mg/dl
  Low-density lipoprotein 96 (78–117) 96 (78–117) 96 (75–116) 0.34
  High-density lipoprotein 34 (28–41) 34 (28–41) 33 (28–40) 0.03
Median triglycerides (interquartile range) — mg/dl 118 (85–170) 118 (85–169) 124 (86–173) 0.52
Median apolipoprotein (interquartile range) — mg/dl
  B 82 (69–96) 82 (69–96) 82 (68–96) 0.86
  A1 116 (103–133) 117 (103–133) 114 (100–129) 0.002
Median fasting glucose (interquartile range) — mg/dl 102 (93–119) 102 (92–117) 106 (94–135) <0.001
Median high-sensitivity C-reactive protein (interquartile range)
— ng/liter
2.4 (1–5.9) 2.3 (1–5.5) 3.9 (1.8–9.8) <0.001
Median myeloperoxidase (interquartile range) — pM 115.2 (76.4–245.7) 113.2 (75.4–238.3) 136.3 (84.7–329.3) <0.001
Median estimated glomerular filtration rate (interquartile range)
— ml/min/1.73 m2
82 (69–95) 83 (71–96) 75 (56–89) <0.001
Median white-cell count (interquartile range) — per mm3 6100 (5100–7500) 6100 (5000–7500) 6400 (5300–8100) 0.001
Medications — %
  Aspirin 74 74 70 0.04
  ACE inhibitor or ARB 50 49 58 <0.001
  Statin 60 61 56 0.06
  Beta-blocker 63 63 65 0.41
Median TMAO (interquartile range) — µM 3.7 (2.4–6.2) 3.5 (2.4–5.9) 5.0 (3.0–8.8) <0.001
*

Plus–minus values are means ±SD. To convert the values for cholesterol to millimoles per liter, multiply by 0.02586. To convert the values for triglycerides to millimoles per liter, multiply by 0.01129. To convert the values for glucose to millimoles per liter, multiply by 0.05551. ACE denotes angiotensin-converting enzyme, ARB angiotensin-receptor blocker, and TMAO trimethylamine-N-oxide.

The P value is for the comparison between patients who had a major adverse cardiovascular event and those who did not.

The body-mass index is the weight in kilograms divided by the square of the height in meters.