Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
p53 generates multiple pro-apoptotic signals, including miR-34a-dependent repression of BCL2. By targeting mRNA of the BH3-only protein BCL2, miR-34a reinforces p53-dependent apoptotic signaling, leading to mitochondrial outer membrane permeabilization, downstream caspase activation and ultimately, apoptosis.
