Table 2.
Activity of Proteasome Inhibitors in Rodent Models of Autoimmune and Inflammatory Diseases
| Disease/model | Inhibitor | Reference |
|---|---|---|
| lupus nephritis | bortezomib | (Neubert et al., 2008) |
| lupus | PR-957 | (Ichikawa et al., 2011) |
| myasthenia gravis | bortezomib | (Gomez et al., 2011) |
| multiple sclerosis | bortezomib | (Fissolo et al., 2008) |
| streptococcal cell-wall induced polyarthritis | bortezomib | (Palombella et al., 1998) |
| rheumatoid arthritis | PR-957 | (Muchamuel et al., 2009) |
| irritant sensitivity | epoxomicin, YU-101 | (Elofsson et al., 1999) |
| psoriasis | PS-519 | (Elliott et al., 2003) |
| asthma | PS-519 | (Elliott et al., 1999) |
| colitis | bortezomib | (Schmidt et al., 2010) |
| PR-957 | (Basler et al., 2010) |