Table 3.
Selected pathways and genes dominantly regulated in dyslipidemic subjects (FO-D) in response to fish oil supplementation for twelve weeks
| Pathway | Gene name | Gene symbol | Entrez_ID | Ratio t12: t0 | |
|---|---|---|---|---|---|
|
Lipid metabolism |
Fatty acid biosynthesis |
acetyl-CoA carboxylase beta |
ACACB |
32 |
-4.67 |
| |
Fatty acid elongation in mitochondria |
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit |
HADHA |
3030 |
-3.70 |
| |
|
hydroxyacyl-CoA dehydrogenase |
HADH |
3033 |
-2.34 |
| |
Fatty acid metabolism |
enoyl-CoA delta isomerase 2 |
ECI2 |
10455 |
-4.54 |
| |
|
enoyl-CoA delta isomerase 1 |
ECI1 |
1632 |
6.02 |
| |
|
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit |
HADHA |
3030 |
-3.70 |
| |
|
hydroxyacyl-CoA dehydrogenase |
HADH |
3033 |
-2.34 |
| |
|
acyl-CoA dehydrogenase, short/branched chain |
ACADSB |
36 |
-13.69 |
| |
|
aldehyde dehydrogenase 2 family (mitochondrial) |
ALDH2 |
217 |
3.26 |
| |
Glycerolipid metabolism |
1-acylglycerol-3-phosphate O-acyltransferase 6 |
AGPAT6 |
137964 |
2.67 |
| |
|
diacylglycerol kinase, alpha 80 kDa |
DGKA |
1606 |
2.47 |
| |
|
diacylglycerol kinase, eta |
DGKH |
160851 |
-3.05 |
| |
|
diacylglycerol kinase, theta 110 kDa |
DGKQ |
1609 |
3.40 |
| |
|
aldehyde dehydrogenase 2 family (mitochondrial) |
ALDH2 |
217 |
3.26 |
| |
|
monoacylglycerol O-acyltransferase 3 |
MOGAT3 |
346606 |
-3.48 |
| |
Glycerophospholipid metabolism |
1-acylglycerol-3-phosphate O-acyltransferase 6 |
AGPAT6 |
137964 |
2.67 |
| |
|
phospholipase B1 |
PLB1 |
151056 |
11.68 |
| |
|
diacylglycerol kinase, alpha 80 kDa |
DGKA |
1606 |
2.47 |
| |
|
diacylglycerol kinase, eta |
DGKH |
160851 |
-3.05 |
| |
|
diacylglycerol kinase, theta 110 kDa |
DGKQ |
1609 |
3.40 |
| |
|
phospholipase A2, group IIE |
PLA2G2E |
30814 |
2.51 |
| |
|
phosphatidylserine synthase 1 |
PTDSS1 |
9791 |
-2.84 |
| |
Arachidonic acid metabolism |
phospholipase B1 |
PLB1 |
151056 |
11.68 |
| |
|
gamma-glutamyltransferase 5 |
GGT5 |
2687 |
7.98 |
| |
|
glutathione peroxidase 3 (plasma) |
GPX3 |
2878 |
-2.15 |
| |
|
glutathione peroxidase 5 |
GPX5 |
2880 |
-2.41 |
| |
|
phospholipase A2, group IIE |
PLA2G2E |
30814 |
2.51 |
| |
Linoleic acid metabolism |
phospholipase B1 |
PLB1 |
151056 |
11.68 |
| |
|
phospholipase A2, group IIE |
PLA2G2E |
30814 |
2.51 |
| |
Alpha-linolenic acid metabolism |
phospholipase B1 |
PLB1 |
151056 |
11.68 |
| |
|
phospholipase A2, group IIE |
PLA2G2E |
30814 |
2.51 |
|
Immune system |
Complement and coagulation cascades |
complement component (3b/4b) receptor 1 |
CR1 |
1378 |
-3.37 |
| |
|
coagulation factor III (thromboplastin, tissue factor) |
F3 |
2152 |
-4.23 |
| |
|
fibrinogen gamma chain |
FGG |
2266 |
-12.30 |
| |
|
serpin peptidase inhibitor, clade C (antithrombin), member 1 |
SERPINC1 |
462 |
3.23 |
|
Cardiovascular diseases |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
desmocollin 2 |
DSC2 |
1824 |
-2.50 |
| |
|
calcium channel, voltage-dependent, gamma subunit 5 |
CACNG5 |
27091 |
-9.92 |
| |
|
integrin, alpha 3 |
ITGA3 |
3675 |
-4.32 |
| |
|
transcription factor 7-like 1 |
TCF7L1 |
83439 |
-4.93 |
| |
Dilated cardiomyopathy |
adenylate cyclase 7 |
ADCY7 |
113 |
-2.13 |
| |
|
calcium channel, voltage-dependent, gamma subunit 5 |
CACNG5 |
27091 |
-9.92 |
| |
|
integrin, alpha 3 |
ITGA3 |
3675 |
-4.32 |
| myosin, light chain 2, regulatory, cardiac, slow | MYL2 | 4633 | 2.68 |