Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation of iNOS-induced metabolic changes in DCs after TLR ligation. Unstimulated DCs can use both glycolysis and mitochondria for their bioenergetic and metabolic needs; however, TLR ligation induces iNOS expression and NO production that in an autocrine fashion inhibits the ETC and mitochondrial function. As a consequence, TLR-activated DCs enhance their glycolytic rate to prevent bioenergetic collapse and cell death.
