Table 3.
Distribution of treatment failures (randomized patients only)
| T-ALL |
T-NHL |
Total |
||||
|---|---|---|---|---|---|---|
| No HDM (n = 151) | HDM (n = 148) | No HDM (n = 66) | HDM (n = 71) | No HDM (n = 217) | HDM (n = 219) | |
| Total failures | 50 | 35 | 9 | 14 | 59 | 49 |
| Induction failures | 14 | 7 | 1 | 1 | 15 | 8 |
| Induction deaths | 1 | 2 | 0 | 0 | 1 | 2 |
| Relapse | 28 | 20 | 5 | 10 | 33 | 30 |
| Marrow only | 4 | 8 | 1 | 1 | 5 | 9 |
| Marrow + CNS | 7 | 1 | 0 | 0 | 7 | 1 |
| Marrow + testicular | 0 | 0 | 0 | 1 | 0 | 1 |
| Marrow + Mediastinal | 1 | 2 | 0 | 1 | 1 | 3 |
| Marrow + other | 1* | 1† | 0 | 1* | 1 | 2 |
| Isolated CNS | 11 | 7‡ | 1 | 2 | 12 | 9 |
| Isolated testicular | 1 | 1 | 0 | 0 | 1 | 1 |
| Mediastinal ± other | 0 | 0 | 2§ | 3¶ | 2 | 3 |
| Lymph | 0 | 0 | 1 | 1 | 1 | 1 |
| Unspecified | 3 | 0 | 0 | 0 | 3 | 0 |
| Second malignancy | 4 | 4 | 2 | 1 | 6 | 5 |
| Remission deaths | 3 | 2 | 1 | 2 | 4 | 4 |
T-ALL indicates T-cell acute lymphoblastic leukemia; T-NHL, T-cell lymphoblastic non-Hodgkin lymphoma; and HDM, high-dose methotrexate.
*
One lymph.
†
One spleen.
‡
One eye.
§
One pleura.
¶
One lung.