Table 1.
Partial list of proximal promoters occupied by HNF1α in human hepatocytes and pancreatic islets. These genes were assigned to functional categories using the program ProtoGo (www.protogo.cs.huji.ac.il). Genes not in this automated Gene Ontology database were assigned on the basis of NCBI information. Four genes are shown for each tissue/category combination; for some combinations, fewer than four promoters qualified as targets. Hypothetical and functionally uncharacterized genes are not shown. A complete list of bound genes, including their accession numbers, is available (20) (tables S2 and S3). HGF, hepatocyte growth factor; Ubiq.-cyt., ubiquinol-cytochrome; IGF insulin-like growth factor; GTP, guanosine 5′-triphosphate; CREB, cyclic adenosine monophosphate response element– binding protein; RAR, retinoic acid receptor; OAT, organic anion transporter; SNAP, N-ethylmaleimide–sensitive factor attachment protein.
| Name | Description | Hepatocytes | Islets |
|---|---|---|---|
| Chaperone | |||
| C4BPA | Complement 4 binding protein α | x | x |
| APCS | Amyloid P component | x | |
| F11 | Coagulation factor XI | x | |
| C1S | Complement component 1s | x | |
| VTN | Somatomedin B | x | |
| Enzyme—hydrolase | |||
| PGCP | Glutamate carboxypeptidase | x | |
| GLA | Galactosidase, α | x | |
| LIPA | Lipase A | x | |
| SPO11 | SPO11-like | x | |
| PAFAH2 | Platelet-activating factor 2 | x | x |
| AADAC | Arylacetamide deacetylase | x | x |
| PS-PLA1 | Phospholipase A1α | x | x |
| VNN3 | Vanin 3 | x | x |
| CPB2 | Carboxypeptidase B2 | x | |
| ANPEP | Alanyl aminopeptidase | x | |
| HGFAC | HGF activator | x | |
| ENPEP | Glutamyl aminopeptidase | x | |
| Enzyme—ligase | |||
| MCCC1 | Methylcrotonoyl-CoA carboxylase | x | |
| GARS | Glycyl-tRNA synthetase | x | |
| TARS | Threonyl-tRNA synthetase | x | |
| Enzyme—lyase | |||
| UROD | Uroporphyrinogen decarboxylase | x | |
| PCK1 | Phosphoenolpyruvate carboxykinase 1 | x | |
| HPCL2 | 2-hydroxyphytanoyl-CoA lyase | x | |
| HAL | Histidine ammonia-lyase | x | |
| FH | Fumarate hydratase | x | |
| Enzyme—oxidoreductase | |||
| COQ7 | COQ7 coenzyme Q, 7 | x | |
| ADH4 | Alcohol dehydrogenase 4 | x | |
| UQCRC2 | Ubiq.-cyt. c reductase core protein II | x | x |
| CYB5-M | Cytochrome b5 | x | x |
| CYP2E | Cytochrome P450, IIE | x | |
| CYB5 | Cytochrome b-5 | x | |
| HSD17B2 | Hydroxysteroid dehydrogenase 2 | x | |
| ADH1A | Alcohol dehydrogenase 1A | x | |
| Enzyme—transferase | |||
| GCNT3 | Glucosaminyl transferase 3 | x | |
| FNTB | Farnesyltransferase β | x | x |
| HNMT | Histamine N-methyltransferase | x | |
| GOT1 | Aspartate aminotransferase 1 | x | |
| UGT2B15 | UDP glycosyltransferase 2B15 | x | |
| GBE1 | Glycogen branching enzyme | x | |
| Enzyme regulator | |||
| SERPING1 | C1-inhibitor | x | |
| SERPINA1 | α-1-antitrypsin | x | |
| ITIH4 | Inter-α inhibitor H4 | x | |
| AHSG | α-2-HS-glycoprotein | x | |
| Ligand binding | |||
| TMOD2 | Tropomodulin 2 | x | |
| IGFBP1 | IGF binding protein 1 | x | |
| MT1X | Metallothionein 1X | x | |
| CRP | C-reactive protein | x | |
| APOA2 | Apolipoprotein A-II | x | |
| Signal transduction—other | |||
| BIKE | BMP-2 inducible kinase | x | |
| SGK2 | Serum/glucocorticoid reg. kinase 2 | x | x |
| SEL1L | Suppressor of lin-12-like | x | x |
| SCYE1 | Small cytokine E1 | x | |
| ANGPTL3 | Angiopoietin-like 3 | x | |
| Signal transduction—receptor | |||
| HAVCR-1 | Hepatitis A virus cellular receptor 1 | x | |
| TACR3 | Tachykinin receptor 3 | x | |
| GNB2L1 | GTP-binding protein, β2-like 1 | x | |
| INSR | Insulin receptor | x | |
| SSTR1 | Somatostatin receptor 1 | x | x |
| TM4SF4 | Transmembrane 4-4 | x | x |
| ASGR2 | Asialoglycoprotein receptor 2 | x | |
| GPR39 | G protein–coupled receptor 39 | x | |
| IFNAR1 | Interferon receptor 1 | x | |
| TFRC | Transferrin receptor | x | |
| Transcription Regulation | |||
| ZNF300 | Kruppel-like zinc finger protein | x | |
| BCL6 | B cell CLL/lymphoma 6 | x | |
| ZNF155 | Zinc finger protein 155 | x | |
| FBX08 | F-box only protein 8 | x | |
| NR0B2 | Small heterodimer protein | x | x |
| HNF4A7 | HNF4α, alternate splice | x | x |
| NR5A2 | LRH-1/FTZ-F1 | x | x |
| ELF3 | E74-like factor 3 | x | x |
| NR1D1 | THRA1 | x | |
| ATF2 | Activating transcription factor 2 | x | |
| CREBL2 | CREB-like 2 | x | |
| RARB | RAR-β | x | |
| Transporter—channel/pore | |||
| SLC17A2 | Vesicular glutamate transporter | x | |
| AQP3 | Aquaporin 3 | x | |
| SLC22A11 | hOAT4 | x | |
| GJB1 | Gap junction protein, β 1 | x | |
| Transporter—lipids and small molecules | |||
| APOH | Apolipoprotein H | x | x |
| ALB | Albumin | x | |
| ABCC2 | Canalicular OAT | x | |
| G6PT1 | Glucose-6-phosphatase, transport | x | |
| Transporter—proteins | |||
| RAB6KIFL | RAB6 interacting, kinesin-like | x | |
| PEX13 | Peroxisome biogenesis factor 13 | x | |
| TMP21 | Transmembrane trafficking protein | x | |
| RAB33B | RAS oncogene | x | x |
| NAPA | α-SNAP | x | |
| AP3M1 | Adaptor-related protein complex | x | |
| SNX17 | Sorting nexin 17 | x | |