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. Author manuscript; available in PMC: 2011 Nov 16.
Published in final edited form as: Cancer Cell. 2010 Nov 16;18(5):436–447. doi: 10.1016/j.ccr.2010.10.022

Figure 6. Loss of Hdac3 leads to hepatocellular carcinoma.

Figure 6

A Representative livers of 5-month (middle panel) and 10-month (right panel) old Alb-Cre:Hdac3−/− mice. B. Survival plot for Alb-Cre:Hdac3−/− mice. Heterozygous mice showed no mortality within this time frame. C. Immunohistochemistry using anti-Hdac3 shows that normal hepatocytes express Hdac3 (left panel), whereas Alb-Cre:Hdac3−/− mice lack Hdac3 both in the tumor and surrounding tissue. T, tumor; L, liver. Scale bar represents 60µm. D. Hematoxylin and eosin stained histological sections (H&E, top panels) and immunohistochemistry for Ki67 (bottom panels) from 10-month old Alb-Cre:Hdac3−/− mice. Scale bar represents 60µm. See also figure S5.