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. Author manuscript; available in PMC: 2010 Oct 11.
Published in final edited form as: J Alzheimers Dis. 2009;17(4):827–844.

Table 5C.

NDEA Treatment Alters Expression of Genes Mediating Temporal Lobe Insulin and IGF Signaling

mRNA* Control (N = 8)* NDEA (N = 16)* P-Value
Insulin Receptor 4.364 ± 0.556 2.521 ± 0.238 0.0003
IGF-I Receptor 2.650 ± 0.277 2.980 ± 0.168
IGF-II Receptor 2.349 ± 0.203 1.439 ± 0.118 0.0001
Insulin 0.038 ± 0.004 0.041 ± 0.004
IGF-I 1.241 ± 0.286 0.634 ± 0.057 0.001
IGF-II 10.11 ± 1.823 12.31 ± 0.995
IRS-1 0.432 ± 0.047 0.677 ± 0.033 < 0.0001
IRS-2 3.996 ± 0.266 2.769 ± 0.183 0.0003
IRS-4 0.142 ± 0.050 0.162 ± 0.034
*

mRNA levels were measured by qRT-PCR and values were normalized to 18s rRNA. Results depict the mean ± S.E.M. (×10−6) for each group. Inter-group statistical comparisons were made using T-test analyses. See abbreviations list in Table 1 legend.

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