Table 4.
Gene expression changes of methylated genes upon demethylation
| N | Chemical demethylation |
Genetic demethylation |
||||
|---|---|---|---|---|---|---|
| Mean changea | P-value | Mean changeb | P-value | |||
| 5′-end methylation | 3031 | 1.57 | <2.2 × 10−16 | 1.81 | 2.2 × 10−16 | |
| No methylation | 16 695 | 1.12 | 1.03 | |||
| 5′-end CpG island methylation | 2465 | 1.63 | 1.1 × 10−3 | 1.91 | 3.6 × 10−4 | |
| 5′-end non CpG island methylation | 566 | 1.33 | 1.45 | |||
| 5′-end non CpG island methylation | 566 | 1.33 | 2.4 × 10−3 | 1.45 | 4.4 × 10−7 | |
| No methylation | 16 695 | 1.12 | 1.03 | |||
| 5′end methylation | 3031 | 1.57 | <2.2 × 10−16 | 1.81 | <2.2 × 10−16 | |
| Genic or 3′-end methylation | 5294 | 0.99 | 0.95 | |||
aAverage of ratios of gene expression in DAC-treated HCT116 cells over those in HCT116 cells.
bAverage of ratios of gene expression in DKO cells over those in HCT116 cells.