Table 2.
Mean (SD) and change scores across time for primary efficacy end points (verbal memory) for women randomized to treatment with CEE/MPA, red clover, black cohosh, and placebo.
| Treatment Group | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Placebo (n = 17) | Red Clover (n = 14) | Black Cohosh (n = 18) | CEE/MPA (n = 17) | |||||||||
| Test, mean score (SD) |
Baseline | 12 months |
Change | Baseline | 12 months |
Change | Baseline | 12 months |
Change | Baseline | 12 months |
Change |
| CVLT | ||||||||||||
| Total learning | 29.06 (6.32) | 28.81 (6.43) | −0.56 (6.31) | 28.50 (7.20) | 27.00 (6.56) | −1.50 (6.89) | 31.39 (4.33) | 28.67 (5.73) | −2.72 (6.47) | 30.82 (6.11) | 26.71 (7.99) | −4.12 (5.01)t |
| Short-delay free recall | 10.12 (2.89) | 8.81 (3.45) | −1.44 (2.80) | 9.14 (3.53) | 8.43 (3.34) | −0.71 (3.20) | 9.56 (2.04) | 8.44 (3.65) | −1.11 (3.20) | 9.24 (2.71) | 8.06 (3.93) | −1.18 (2.60) |
| Long-delay free recall | 9.82 (3.61) | 9.31 (3.30) | −1.25 (3.53) | 9.14 (3.76) | 8.07 (4.43) | −0.71 (4.03) | 10.39 (1.91) | 10.17 (2.92) | −1.94 (3.84) | 10.41 (2.55) | 9.18 (3.36) | −2.35 (2.89) |
| LM | ||||||||||||
| Immediate total score | 13.88 (4.34) | 13.47 (3.04) | −0.41 (3.64) | 12.79 (3.09) | 12.36 (3.05) | −0.43 (4.40) | 14.39 (3.11) | 14.33 (3.61) | −0.06 (3.84) | 13.35 (4.03) | 13.59 (3.12) | 0.24 (3.46) |
| Delayed total score | 12.35 (4.66) | 12.12 (3.30) | −0.23 (4.28) | 12.64 (3.10) | 11.07 (3.25) | −1.57 (4.29) | 14.22 (3.17) | 12.89 (3.38) | −1.33 (2.93) | 12.65 (4.03) | 12.35 (3.71) | −0.29 (4.18) |
Note. CVLT = California Verbal Learning Test List A. LM = Logical Memory Test.
t
p > 0.05 and p < 0.10 compared with placebo.