TABLE 2.
Hazard ratios (HRs) and 95% CIs for additional breast cancer events after 7.3 y of follow-up according to baseline dietary quartiles (Qs) in the subgroup of women without hot flashes
| No. of participants (no. of additional breast cancer events) |
|||||
| Dietary component | All | Intervention | Comparison | HR1 (95% CI) | P for trend2 |
| All | 896 (179) | 446 (72) | 450 (107) | 0.7 (0.52, 0.95) | |
| Vegetables–fruit | 0.01 | ||||
| Q1: ≤4.9, servings/d | 249 (61) | 124 (26) | 125 (35) | 0.8 (0.48, 1.35) | |
| Q2: >4.9–6.7 servings/d | 222 (37) | 108 (18) | 114 (19) | 0.99 (0.51, 1.94) | |
| Q3: >6.7–8.9 servings/d | 210 (45) | 110 (18) | 100 (27) | 0.56 (0.31, 1.03) | |
| Q4: >8.9 servings/d | 215 (36) | 104 (10) | 111 (26) | 0.41 (0.19, 0.86) | |
| Fiber | 0.02 | ||||
| Q1: ≤15.6 g/d | 227 (45) | 113 (19) | 114 (26) | 0.82 (0.45, 1.48) | |
| Q2: >15.6–19.9 g/d | 226 (42) | 117 (20) | 109 (22) | 0.79 (0.42, 1.47) | |
| Q3: >19.9–25.2 g/d | 216 (42) | 107 (17) | 109 (25) | 0.99 (0.52, 1.89) | |
| Q4: >25.2 g/d | 227 (50) | 109 (16) | 118 (34) | 0.48 (0.26, 0.87) | |
| Energy from fat | 0.06 | ||||
| Q1: ≤23.8%/d | 229 (34) | 117 (11) | 112 (23) | 0.42 (0.2, 0.88) | |
| Q2: >23.8–28.6%/d | 214 (51) | 106 (25) | 108 (26) | 0.88 (0.5, 1.55) | |
| Q3: >28.6–33.4%/d | 228 (51) | 112 (19) | 116 (32) | 0.69 (0.38, 1.26) | |
| Q4: >33.4%/d | 225 (43) | 111 (17) | 114 (26) | 0.75 (0.4, 1.43) | |
| Fiber-to-fat ratio3 | 0.01 | ||||
| Q1: ≤0.25 | 221 (37) | 104 (15) | 117 (22) | 0.82 (0.42, 1.63) | |
| Q2: >0.25–0.36 | 237 (50) | 119 (22) | 118 (28) | 0.81 (0.45, 1.43) | |
| Q3: >0.36–0.54 | 221 (52) | 123 (24) | 98 (28) | 0.69 (0.39, 1.23) | |
| Q4: >0.54 | 217 (40) | 100 (11) | 117 (29) | 0.38 (0.19, 0.77) | |
1
Derived from Cox model adjusted for stage and grade of original tumor and antiestrogen therapy.
2
Linear trend test for intervention effect across quartiles of baseline dietary pattern in multiple Cox model; likelihood ratio tests for group quartile interaction were not significant for any diet component.
3
Fiber (g/d) divided by fat (g/d).