Figure 6.
AP lesions abolished the hyperphagic response to 3V injection of ORXA (1 nm). A, Mean (+ se) meal size (milliliters) values after aCSF (white bar) and ORXA (black bars) injections in 3V cannula-fitted sham operated rats (n = 8) ingesting water and 0.1 and 1 m sucrose solutions. ORXA increased meal size overall [drug F(1,7) = 16.91; P < 0.005] and specifically for 0.1 m sucrose [t(7) = −2.61; *, P = 0.035]. B, Same conditions as A for 3V cannula-fitted AP/NST lesioned rats (APX; n = 17). There was no significant effect of drug [F(1,16) = 0.80, NS] and no significant interaction [F(2,32) = 0.70, NS], and the paired comparison for 0.1 m sucrose was not significant [t(16) = −0.86, NS].