TABLE 2.
Clamp parameters during final 90 min of study
| Parameter | Y-AL
|
O-CR
|
O-AL
|
|||
|---|---|---|---|---|---|---|
| Saline | GlcN | Saline | GlcN | Saline | GlcN | |
| n | 6 | 6 | 4 | 5 | 4 | 5 |
| Rd | 21.2 ± 0.4 | 13.5 ± 0.1* | 17.8 ± 0.3 | 9.8 ± 0.4*,^ | 14.2 ± 0.3^ | 13.3 ± 0.1§,^ |
| GIR | 14.0 ± 1.1 | 8.5 ± 2.4 | 9.4 ± 3.8 | 3.6 ± 2.0* | 5.2 ± 1.4^ | 2.6 ± 1.2*,# |
| HGP | 5.0 ± 1.2 | 6.3 ± 1.7 | 5.2 ± 1.1 | 7.5 ± 0.4 | 8.1 ± 1.1 | 11.0 ± 0.8*,#,§ |
| Glycolysis | 10.3 ± 1.0 | 8.8 ± 1.2 | 8.8 ± 1.0 | 5.0 ± 0.6 | 4.9 ± 0.5^ | 6.0 ± 1.1 |
| Glycogen synthesis | 9.6 ± 0.7 | 5.6 ± 1.3* | 8.3 ± 2.3 | 3.8 ± 0.5* | 8.6 ± 1.9 | 6.1 ± 1.0 |
Glycolysis and glycogen synthesis values were averaged over the last 90 min of the study. All data expressed as means ± se. GIR, glucose infusion rate; HGP, hepatic glucose production.
*
P < 0.01 vs. saline control in same group;
#
P < 0.01 vs. young GlcN;
§
P < 0.01 vs. O-CR GlcN;
^
P < 0.01 vs. young saline.