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. 1999 Mar;79(7-8):1049–1052. doi: 10.1038/sj.bjc.6690168

Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3

A-M Cleton-Jansen 1, E W Moerland 1, J C Pronk 2, C G M van Berkel 2, S Apostolou 3, J Crawford 3, A Savoia 4, A D Auerbach 5, C G Mathew 6, D F Callen 3, C J Cornelisse 1
PMCID: PMC2362253  PMID: 10098735

Abstract

The recently identified Fanconi anaemia A (FAA) gene is located on chromosomal band 16q24.3 within a region that has been frequently reported to show loss of heterozygosity (LOH) in breast cancer. FAA mutation analysis of 19 breast tumours with specific LOH at 16q24.3 was performed. Single-stranded conformational polymorphism (SSCP) analysis on cDNA and genomic DNA, and Southern blotting failed to identify any tumour-specific mutations. Five polymorphisms were identified, but frequencies of occurrence did not deviate from those in a normal control population. Therefore, the FAA gene is not the gene targeted by LOH at 16q24.3 in breast cancer. Another tumour suppressor gene in this chromosomal region remains to be identified. © 1999 Cancer Research Campaign

Keywords: Fanconi anaemia, breast cancer, allelic imbalance, tumour suppressor gene, chromosome 16

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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