Figure 2.
Increased numbers of effector/memory and autoreactive T cells in spleens of Bcl-3, NF-κB2 double knockout (dKO) mice. (a) Splenocytes from 26-day-old NF-κB2 KO and dKO mice were examined with flow cytometry for the expression of CD44 and CD62L on CD4+ and CD8+ T cells, as shown. (b) CD4+ T cells purified from spleens of 26-day-old Bcl-3 KO, NF-κB2 KO and dKO mice were cultured with or without irradiated syngeneic antigen-presenting cells (APCs) (see Methods) and pulsed with [3H]thymidine. Data are the mean of triplicates.