FIG. 7.
Maintenance of the erythroid-specific composite histone modification pattern of the β-globin locus does not require ongoing transcriptional elongation by Pol II. Samples analyzed by ChIP for Pol II binding in Fig. 3 were also used to detect DRB-induced changes in histone acetylation and H3-meK4 at the βmajor gene and at the LCR. The graphs show the relative intensities of PCR products from three or four independent experiments (mean and standard error of the mean). PI, rabbit preimmune serum.